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The Combination Very Low-Dose Naltrexone-Clonidine in the Management of Opioid Withdrawal.

Conclusions and Scientific Significance: Preliminary results elucidate neurobiological mechanisms of OD and support the utility of controlled studies on a novel VLNTX + low-dose clonidine combination for the management of opioid withdrawal. Portions of this article were presented at the American Society of Addiction Medicine, 42nd Annual Medical Scientific Conference, April 14-17, 2011, in Washington, DC. PMID: 22233189 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)

LETTER: Reader’s view: Dusseau column struck a nerve with tobacco industry

Apparently the useful public service opinion piece by Susan Dusseau, “Smokeless Tobacco — The New Norm?,” hit a little too close to home for the tobacco industry, as evidenced by no less than two articles printed on the editorial page of the MDN on Sunday, Nov.

Star Scientific May Be ‘One Up On Wall Street’

Peter Lynch’s legendary book “One Up on Wall Street” encourages retail investors to search for and find “tenbaggers” before they become widely known. He suggests that we, as individual investors, can occasionally find opportunities on Main Street USA before the investment professionals on Wall Street discover them.

Governing through problems: The formulation of policy on amphetamine-type stimulants (ATS) in Australia

Abstract: Producing and implementing credible and effective policies on illicit drug use is generally seen as an important aspect of health governance in the West.

ROSS: A response to ‘Smokeless tobacco — The new norm?’

If Susan Dusseau, as director of Cancer Services, is serious about reducing the toll of cancer among smokers, she should learn a bit more of the fact- and evidence-based data concerning the real causes of tobacco-related cancer before shooting from the hip on this important subject. Her recent article, “Smokeless tobacco –The new norm?,” is filled with half-truths and errors which, in sum, will increase rather than reduce the number of smoking-related illnesses.

Alcohol… all in the mind? BBC news piece challenges the ‘alcohol message’

A recent BBC news magazine article, Is the alcohol message all wrong? , has challenged the validity of current alcohol education campaigns. Social anthropologist Kate Fox posed the provocative question..

Scientific Evaluation of Modified Risk Tobacco Product Applications; Public Workshop; Request for Comments: A Notice by the Food and Drug…

This article has a comment period that ends in 1 day (09/23/2011) . . .

Zero-Inflated and Hurdle Models of Count Data with Extra Zeros: Examples from an HIV-Risk Reduction Intervention Trial.

Conclusions and Scientific Significance: This article illustrates the consequences of applying models with different distribution assumptions on the data. If a model used does not closely fit the shape of the data distribution, the estimate of the effect of the intervention may be biased, either over- or underestimating the intervention effect. PMID: 21854279 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)

Site selection in community-based clinical trials for substance use disorders: strategies for effective site selection.

Conclusion: This article describes considerations for selecting research sites and identifies specific strategies to employ when selecting community-based sites for participation in clinical trials. PMID: 21854283 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)

Baseline matters: the importance of covariation for baseline severity in the analysis of clinical trials.

Conclusions and Scientific Significance: This article illustrates principles of covariation for baseline and the baseline-by-treatment interaction in nontechnical graphical terms, and discusses examples from clinical trials.