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Tag Archives: clinical

Moderate Alcohol Intake Linked To Lower Female Diabetes Risk

Females in middle age who drink alcohol moderately and consume large amounts of refined carbohydrates have a 30% lower chance of developing diabetes type 2, compared to women with similar dietary habits who don’t drink, researchers from the Harvard School of Public Health wrote in the American Journal of Clinical Nutrition…

Vanderbilt Study Finds Alcoholics’ ‘Injured Brains’ Work Harder To Complete Simple Tasks

Alcoholic brains can perform a simple finger-tapping exercise as well as their sober counterparts but their brain must work a lot harder to do it, according to a Vanderbilt study released today by the journal, Alcoholism: Clinical & Experimental Research. Chronic drinking is associated with abnormalities in the structure, metabolism and function of the brain…

Comparative profiles of men and women with opioid dependence: results from a national multisite effectiveness trial.

Conclusions: Important gender differences in the clinical profiles of opioid-dependent individuals were observed with regard to substance use severity, craving, medical conditions, and impairment in associated areas of functioning. The findings enhance understanding of the characteristics of treatment-seeking men and women with opioid dependence, and may be useful in improving identification, prevention, and treatment efforts for this challenging and growing population

Standardized patient walkthroughs in the national drug abuse treatment clinical trials network: common challenges to protocol implementation.

Conclusions and Scientific Significance: Standardized patient walkthroughs capture issues with study procedures previously unidentified with didactic training or unscripted rehearsals. Clinical trials within the National Drug Abuse Treatment Clinical Trials Network are conducted in addiction treatment centers that vary on multiple dimensions. Based on walkthrough observations, the national protocol team and local site leadership modify standardized operating procedures and resolve cross-site problems prior to recruiting study participants

Patient and clinician’s ratings of improvement in methadone-maintained patients: Differing perspectives?

Background: In the last few years there seems to be an emerging interest for including the patients’ perspective in assessing methadone maintenance treatment (MMT), with treatment satisfaction surveys being the most commonly-used method of incorporating this point of view. The present study considers the perspective of patients on MMT when assessing the outcomes of this treatment, acknowledging the validity of this approach as an indicator

The relationship between self-reported substance use and psychiatric symptoms in low-threshold methadone maintenance treatment clients

Background: Ongoing psychiatric symptoms and substance use are common difficulties experienced by clients enrolled in methadone maintenance treatment (MMT). However, little research to date has evaluated if specific types of current substance use are related to specific types of current psychiatric symptoms.

Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?

ABSTRACT The compulsive use of dopamine replacement therapy (DRT) or dopamine dysregulation syndrome (DDS) is one of the behavioural disturbances reported in some patients with Parkinson’s disease (PD) and other disorders who are receiving DRT. We draw this phenomenon to the attention of the addiction field as a topic deserving of more systematic study. We outline: the clinical features, epidemiology and clinical correlates of the disorder; the unresolved issues in its definition and diagnosis; and its potential relevance to neurobiological models of psychostimulant addiction

Primary outcome indices in illicit drug dependence treatment research: systematic approach to selection and measurement of drug use end-points in…

ABSTRACT AimsĀ  Clinical trials test the safety and efficacy of behavioral and pharmacological interventions in drug-dependent individuals. However, there is no consensus about the most appropriate outcome(s) to consider in determining treatment efficacy or on the most appropriate methods for assessing selected outcome(s)

Binge Drinking Damages Teenage Girls’ Brains More Than Boys’

Teenage girls who binge-drink have a higher risk of long-term harm to the brain compared to boys of the same age who also binge drink, researchers from the University of California, San Diego and Stanford University reported in Alcoholism: Clinical and Experimental Research…

Energy Drink Plus Alcohol Cocktail Raises Risks Linked To Drinking More Than Alcohol By Itself

Mixing energy drinks, such as Red Bull with alcohol is probably more hazardous than consuming alcohol alone, researchers from Northern Kentucky University revealed in the journal Alcoholism: Clinical & Experimental Research…