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Tag Archives: cocaine

Influence of acute bupropion pre-treatment on the effects of intranasal cocaine

Saturday, February 11, 2012

ABSTRACT Aims  The aim of this experiment was to determine the influence of acute bupropion pre-treatment on subject-rated effects and choice of intranasal cocaine versus money. Design  A randomized, within-subject, placebo-controlled, double-blind experiment. Setting  An out-patient research unit

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A longitudinal study of substance use and violent victimization in adulthood among a cohort of urban African Americans

Wednesday, February 1, 2012

ABSTRACT Aims  This paper examines the effects of experiencing violent victimization in young adulthood on pathways of substance use from adolescence to mid-adulthood. Design  Data come from four assessments of an African American community cohort followed longitudinally from age 6 to 42 years. Setting  The cohort lived in the urban, disadvantaged Woodlawn neighborhood of Chicago in 1966

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Sex work involvement among women with long-term opioid injection drug dependence who enter opioid agonist treatment

Wednesday, January 25, 2012

Background: Substitution with opioid-agonists (e.g., methadone) has shown to be an effective treatment for chronic long-term opioid dependency.

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Implementation and Evaluation of a Harm-Reduction Model for Clinical Care of Substance Using Pregnant Women

Thursday, January 19, 2012

Background: Methamphetamine (MA) use during pregnancy is associated with many pregnancy complications, including preterm birth, small for gestational age, preeclampsia, and abruption. Hawaii has lead the nation in MA use for many years, yet prior to 2007, did not have a comprehensive plan to care for pregnant substance-using women. In 2006, the Hawaii State Legislature funded a pilot perinatal addiction clinic

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How The Brain Puts The Brakes On The Negative Impact Of Cocaine

Friday, January 13, 2012

Research published by Cell Press in the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective delayed mechanism that turns off the genes that support the development of addiction-related behaviors…

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The Efficacy of Mirtazapine in the Treatment of Cocaine Dependence with Comorbid Depression.

Thursday, January 5, 2012

Conclusions and Scientific Significance: The results of this study suggest that mirtazapine is superior to placebo in improving sleep in patients with comorbid depression and cocaine dependence, but is not more effective than placebo in reducing cocaine use.

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Increased incidence of QT interval prolongation in a population receiving lower doses of methadone maintenance therapy

Tuesday, December 13, 2011

ABSTRACT Aims:  The aim of the study was to investigate the frequency of corrected QT interval (QTc) prolongation in a methadone maintenance therapy (MMT) population, and to examine potential associations between this QTс interval and methadone dose as well as concurrent use of opiates, cocaine, and benzodiazepines. Design:  Cross-sectional study of patients attending a specialist drug treatment clinic from July 2008 to January 2009. Setting:  Single centre inner city specialist drug treatment clinic Ireland

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Influence of Acute Bupropion Pretreatment on the Effects of Intranasal Cocaine

Tuesday, December 13, 2011

Abstract Aims: The aim of this experiment was to determine the influence of acute bupropion pretreatment on subject-rated effects and choice of intranasal cocaine versus money. Design: A randomized, within-subject, placebo-controlled, double-blind experiment. Setting: An outpatient research unit

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Non-medical use of opioids among HIV-infected opioid dependent individuals on opioid maintenance treatment: the need for a more comprehensive approach

Monday, November 28, 2011

Background: Opioid maintenance treatment (OMT) has a positive impact on substance use and health outcomes among HIV-infected opioid dependent patients. The present study investigates non-medical use of opioids by HIV-infected opioid-dependent individuals treated with buprenorphine or methadone. Methods: The MANIF 2000 study is a longitudinal study that enrolled a cohort of 476 HIV-infected opioid-dependent individuals.

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Brain Primed By Nicotine For Cocaine Use: Molecular Basis Of Gateway Sequence Of Drug Use

Friday, November 4, 2011

Cigarettes and alcohol serve as gateway drugs, which people use before progressing to the use of marijuana and then to cocaine and other illicit substances; this progression is called the “gateway sequence” of drug use…

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